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CBSE Class 12 Biotechnology Sample Paper 2024-25, Download PDF with Answers

The newly updated CBSE Class 12th Biotechnology Sample Paper 2024-25 has been released by the Central Board of Secondary Education [CBSE]. All the class 12th students who have Biotechnology as a subject in their final exams must visit the online portal of CBSE at www.cbseacademic.nic.in to download the CBSE Class 12 Biotechnology Sample Paper 2024-25. This will allow them to download the PDF files of these sample papers to complete preparations.

These practice papers will help them to understand and familiarize themselves with the actual level of questions in the question paper. We have provided the direct link to download the CBSE Class 12 Biotechnology Sample Paper 2024 below.

CBSE Class 12 Biotechnology Sample Paper 2024-25

CBSE Class 12 Biotechnology sample papers are useful for exam preparation. They include multiple-choice, short-answer, and long-answer questions. The main topics in the syllabus are Genetic Engineering, Plant Biotechnology, Microbial Biotechnology, and Bioinformatics.

By solving these sample papers, students can understand the types of questions, marking patterns, and important topics. This helps them plan their studies better and boosts their confidence for the exam. Practicing with these papers also gives students a clear idea of how to answer questions effectively. Overall, using these sample papers is a smart way to prepare for the exam and improve their performance.

Class 12 Biotechnology Sample Paper 2024-25 PDF With Solutions

The CBSE Class 12 Biotechnology sample paper PDF with solutions helps students by giving them a clear idea of the exam pattern and types of questions. By practicing these papers, students can understand important topics, improve time management, and build confidence for the exam. The solutions guide students on how to write correct answers and score better. It is a great way to revise and prepare effectively, as students can identify their mistakes and work on weak areas. To provide easy access to the CBSE Class 12 Sample Paper 2024-25 for Biotechnology along with the solution PDF, we have also provided a direct link below.

Class 12 Biotechnology Sample Paper 2024-25 PDF With Solutions
Sample Paper PDF Solution PDF
Class 12 Biotechnology Sample Paper 2024-25 PDF  Solution Link

CBSE Class 12 Biotechnology Question Paper Pattern 2025

The Class 12 Biotechnology question paper has 33 questions divided into 5 sections. Students must answer all the questions within 3 hours. The total marks for the Biotechnology paper are 70. We have provided a detailed breakdown of how the questions are organized in the article below. This information will help students understand the format of the exam and manage their time effectively while preparing.

  1. Section–A contains 12 Multiple choice questions and 4 Assertion-Reasoning based questions of 1 mark each;
  2. Section–B has 5 short answer questions of 2 marks each;
  3. Section –C has 7 short answer questions of 3 marks each;
  4. Section D has two case-based questions of 4 marks;
  5. Section E has three long answer questions of 5 marks each.
  6. All questions are compulsory.
  7. There is no overall choice. However, internal choices have been provided in some questions. A student has to attempt only one of the alternatives in such questions.
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Download Class 12 Biotechnology Sample Paper PDF with Solutions (Previous Year)

Class 12 students preparing for the Biotechnology final exam can now practice and check their knowledge using previous years’ Biotechnology sample papers and solutions. These papers help students understand the exam pattern and improve their performance. The table below provides links to year-wise sample papers along with their marking schemes. Using these resources will help students get familiar with important questions and scoring strategies, making their preparation more effective and boosting their confidence for the final exam.

CBSE Class 12 Biotechnology Sample Paper 
Year Subject Sample Question Paper (SQP) Marking Scheme (MS)
2023 Biotechnology Click Here Click Here
2022 Biotechnology Click Here Click Here
2021 Biotechnology (Term 1) Click Here Click Here
Biotechnology (Term 2) Click Here Click Here

CBSE Class 12 Biotechnology Sample Paper With Answers

Section – A

Q. No. 1 to 12 are multiple choice questions. Only one of the choices is correct. Select and write the correct choice as well as the answer to these questions.

Q1. An approach that utilises analysis of genome present in different environments to screen the presence of a variety of molecules.

A. Metagenomics
B. Proteomics
C. Strain preservation
D. Mutant selection

Answer: A. Metagenomics

Q2. In animal cell culture, the CO2 levels in the incubator is usually maintained at

A. 1-2%
B. 3-4%
C. 5-10%
D. 11-15%

Answer: C. 5-10% 

Q3. Even if we know where the genes are in each genome, it’s difficult to count them due to:

(i) splice variants
(ii) overlapping genes
(iii) Post-transcriptional events
(iv) Mutations

A. (i), (iii)
B. (i), (ii)
C. (iii), (iv)
D. (ii), (iv)

Answer: B. (i) and (ii)

Q4. Avocado growers in Kerela want to find a way to genetically engineer their crop to prevent it from ripening during shipping. This can be achieved by introducing

A. genes for carotenoid biosynthesis.
B. gene from Bacillus amyloliquefaciens.
C. ethylene forming gene(s).
D. gene for protein containing sulphur-rich amino acids.

Answer: C. ethylene forming gene(s) 

Q5. Microbial species used for commercial production of citric acid is

A. Saccharomyces cerevisiae
B. Aspergillus niger
C. Streptomyces griseus
D. Aspergillus oryzae

Answer: B. Aspergillus niger

Q6. To reduce the possibility of religation of vector without picking insert, the following method or methods may be used-

(i) Use of DNA Ligase
(ii) Use of Alkaline Phosphatase
(iii) Use of two different Restriction enzymes for cloning
(iv) Hybridoma technology

Select the correct answer from options below

A. (i), (iv)
B. (ii), (iii)
C. (iii), (iv)
D. (ii), (iv)

Answer: D. (ii) and (iii)

Q7. In a comparative cDNA microarray, the cDNA obtained from the normal and diseased cells are labelled with red and green fluorescent dyes respectively. The yellow color of the spot indicates

A. Gene is expressed only in normal cells.
B. Gene is not expressed either in normal cells or in diseased cells.
C. Gene expressed only in diseased cells.
D. Gene expressed in equal measure in both types of cells.

Answer: D. Gene expressed in equal measure in both types of cells.

Q8. Which disease has its locus on chromosomes number 1 and 6?

A. Huntington’s disease
B. Migraine
C. Alzheimer’s disease
D. Cystic fibrosis

Answer: B. Migraine

Q9. A molecular disease which leads to increased hydrophobic interactions within the haemoglobin protein is

A. Thalassemia
B. Sickle Cell anaemia
C. Mad Cow
D. SCID

Answer: B. Sickle Cell Anaemia

Q10. Interleukin-2 produced using the CHO cell line is used for

A. anaemia therapy.
B. cancer therapy.
C. stroke.
D. treatment of autoimmune disease.

Answer: B. Cancer therapy.

Q11. Proteome of a given cell is dynamic because:

A. In response to internal and external changes the biochemical machinery of the cell could be changed.
B. In response to internal and external changes the biochemical machinery of the cell could not be changed.
C. No direct relationship exists between internal and external changes in the biochemical machinery of the cell.
D. Indirect relationship exists between internal and external in changes the biochemical machinery of the cell.

Answer: A. In response to internal and external changes the biochemical machinery of the cell could be changed. 

Q12. A novel gene that codes for the epitope has been introduced into yeast cells to produce

A. Hepatitis B Vaccine
B. Subtilisin
C. EPO
D. tPA

Answer: A. Hepatitis B vaccine

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