CBSE Class 12 Biotechnology Sample Paper 2024-25, Download PDF with Answers

The newly updated CBSE Class 12th Biotechnology Sample Paper 2024-25 has been released by the Central Board of Secondary Education [CBSE]. All the class 12th students who have Biotechnology as a subject in their final exams must visit the online portal of CBSE at www.cbseacademic.nic.in to download the CBSE Class 12 Biotechnology Sample Paper 2024-25. This will allow them to download the PDF files of these sample papers to complete preparations.

These practice papers will help them to understand and familiarize themselves with the actual level of questions in the question paper. We have provided the direct link to download the CBSE Class 12 Biotechnology Sample Paper 2024 below.

CBSE Class 12 Biotechnology Sample Paper 2024-25

CBSE Class 12 Biotechnology sample papers are valuable resources that help students prepare effectively for their exams. These papers typically follow a structured pattern, which includes multiple-choice questions, short-answer questions, and long-answer questions. Key topics covered in the syllabus include Genetic Engineering, Plant Biotechnology, Microbial Biotechnology, and Bioinformatics. The sample papers provide insights into the types of questions asked, the marking scheme, and the important concepts to focus on, aiding students in their revision and boosting their confidence for the final exam.

Class 12 Biotechnology Sample Paper 2024-25 PDF With Solutions

The CBSE Class 12 Biotechnology sample paper PDF with solutions helps students by giving them a clear idea of the exam pattern and types of questions. By practicing these papers, students can understand important topics, improve time management, and build confidence for the exam. The solutions guide students on how to write correct answers and score better. It is a great way to revise and prepare effectively, as students can identify their mistakes and work on weak areas. To provide easy access to the CBSE Class 12 Sample Paper 2024-25 for Biotechnology along with the solution PDF, we have also provided a direct link below.

CBSE Class 12 Biotechnology Question Paper Pattern 2025

The CBSE Class 12 Biotechnology question paper has 33 questions divided into five sections. Section A has 16 very short answer questions of 1 mark each. Section B has 6 short answer questions worth 2 marks each. Section C includes 5 questions, each carrying 3 marks. Section D has 3 long answer questions of 5 marks each.

Finally, Section E contains 3 case-based questions, each carrying 4 marks. The paper is designed to assess a mix of theoretical knowledge, application, and analytical skills. All questions are compulsory, but internal choices are provided in some sections. Wherever necessary, neat and properly labeled diagrams should be drawn.

1. Section–A contains 12 Multiple choice questions and 4 Assertion-Reasoning based questions of 1 mark each;
2. Section–B has 5 short answer questions of 2 marks each;
3. Section –C has 7 short answer questions of 3 marks each;
4. Section D has two case-based questions of 4 marks;
5. Section E has three long answer questions of 5 marks each.
6. All questions are compulsory.
7. There is no overall choice. However, internal choices have been provided in some questions. A student has to attempt only one of the alternatives in such questions.

Download Class 12 Biotechnology Sample Paper PDF with Solutions (Previous Year)

The table below contains the links to access the previous year’s CBSE Class 12 Biotechnology Sample Papers 2024-25 in PDF format along with their solutions. All the students who are preparing to appear in the Biotechnology exam must now click on the direct links below and access the sample papers to finalize their preparations.

CBSE Class 12 Biotechnology Sample Paper With Answers

Section – A

Q. No. 1 to 12 are multiple choice questions. Only one of the choices is correct. Select and write the correct choice as well as the answer to these questions.

Q1. An approach that utilises analysis of genome present in different environment to screen presence of a variety of molecules.

A. Metagenomics
B. Proteomics
C. Strain preservation
D. Mutant selection

Answer: A. Metagenomics

Q2. In animal cell culture, the CO2 levels in the incubator is usually maintained at

A. 1-2%
B. 3-4%
C. 5-10%
D. 11-15%

Answer: C. 5-10% 

Q3. Even if we know where the genes are in each genome, it’s difficult to count them due to:

(i) splice variants
(ii) overlapping genes
(iii) Post – transcriptional events
(iv) Mutations

A. (i), (iii)
B. (i), (ii)
C. (iii), (iv)
D. (ii), (iv)

Answer: B. (i) and (ii)

Q4. Avocado growers in Kerela want to find a way to genetically engineer their crop to prevent it from ripening during shipping. This can be achieved by introducing

A. genes for carotenoid biosynthesis.
B. gene from Bacillus amyloliquefaciens.
C. ethylene forming gene(s).
D. gene for protein containing sulphur-rich amino acids.

Answer: C. ethylene forming gene(s) 

Q5. Microbial species used for commercial production of citric acid is

A. Saccharomyces cerevisiae
B. Aspergillus niger
C. Streptomyces griseus
D. Aspergillus oryzae

Answer: B. Aspergillus niger

Q6. To reduce the possibility of religation of vector without picking insert, the following method or methods may be used-

(i) Use of DNA Ligase
(ii) Use of Alkaline Phosphatase
(iii) Use of two different Restriction enzymes for cloning
(iv) Hybridoma technology

Select the correct answer from options below

A. (i), (iv)
B. (ii), (iii)
C. (iii), (iv)
D. (ii), (iv)

Answer: D. (ii) and (iii)

Q7. In a comparative cDNA microarray, the cDNA obtained from the normal and diseased cells are labelled with red and green fluorescent dyes respectively. The yellow colour of the spot indicates

A. Gene is expressed only in normal cells.
B. Gene is not expressed either in normal cells or in diseased cells.
C. Gene expressed only in diseased cells.
D. Gene expressed in equal measure in both types of cells.

Answer: D. Gene expressed in equal measure in both types of cells.

Q8. Which disease has its locus on chromosome no 1 and 6?

A. Huntington’s disease
B. Migraine
C. Alzheimer’s disease
D. Cystic fibrosis

Answer: B. Migraine

Q9. A molecular disease which leads to increased hydrophobic interactions within the haemoglobin protein is

A. Thalassemia
B. Sickle Cell anaemia
C. Mad Cow
D. SCID

Answer: B. Sickle Cell Anaemia

Q10. Interleukin-2 produced using CHO cell line is used for

A. anaemia therapy.
B. cancer therapy.
C. stroke.
D. treatment of autoimmune disease.

Answer: B. Cancer therapy 

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